Senti Bio is a clinical-stage company that has built a synthetic biology platform that enables us to program next-generation cell and gene therapies with Gene Circuits. Our lead product candidates utilize off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cells outfitted with Gene Circuit technologies in several oncology indications with high unmet need.

Gene Circuit Engineering: Pursuing New Classes of Cell and Gene Therapies

Gene Circuits are created from novel and proprietary combinations of DNA sequences to reprogram cells with biological logic to sense inputs, compute decisions and respond to their cellular environments. We believe that our approach to programming Gene Circuits is broadly applicable toward engineering optimal efficacy, precision and control into cell or gene-based medicines.

Senti Bio’s Gene Circuit technologies are the foundation for developing smarter medicines that are designed to precisely kill diseased cells, spare healthy cells, increase specificity to target cells and control the expression of drugs even after administration.